Endocrinology Question 18 Instructor

Alice Smyth is a 42 year-old woman who is referred to you by a neurosurgeon who saw her for carpal tunnel syndrome, but became concerned that she may have acromegaly.

List 10 clinical manifestations of acromegaly.

  • Facial changes:
    • proganthism
    • enlarged nose/tongue
    • frontal bossing
  • Enlarged hands and feet
  • Cardiomegaly/CHF
  • Metabolic syndrome:
    • hypertension
    • hypertriglyceridemia
    • diabetes mellitus
  • Osteoporosis
  • Hypercalcemia
  • BPH
  • Multinodular goiter
  • Carpal tunnel syndrome
  • Obstructive sleep apnea
  • Colonic polyps
  • Skin tags, hyperhydrosis

How do you screen for and confirm the diagnosis of acromegaly?

Screen for elevated IGF-1 level.

Diagnose with 2 hour 75 g glucose suppression test.
If normal: GH suppresses to <1

Subscribe to Pearls

Uncle Sam wants you to subscribe to Medical Pearls

Subscribe today! It’s always free, and you can easily unsubscribe at any time. We will never share your email address. Subscribe to...

Multiple Pearls
Cardiology Pearls
Endocrinology Pearls
Hematology Pearls
Nephrology Pearls
Rheumatology Pearls
Transplant Pearls
General Internal Medicine Pearls
Instructor Pearls

Subscribe to receive your pearls today—it's free!