Endocrinology Question 23 Instructor

List 4 genetic syndromes which are associated with pheochromocytoma. What are the other manifestations of these syndromes?

Syndrome	Other manifestations
MEN 2A and 2B	2A: hyper PTH medullary thyroid cancer (MTC) pheo 2B: MTC pheo mucosal neuromas
Von Hippel Lindau	Renal cell carcinoma, hemangioblastoma (retina, cerebellar), endolymphatic middle ear tumours, pancreatic tumours
Neurofibromatosis-1	Café au lait spots, neurofibromas
SDHA, SDHB, SDHC, SDHD	Paragangliomas (extra-adrenal pheos), SDHB: renal cell ca

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