Endocrinology Question 38 Instructor

How do you treat DI?

  • If hypernatremic, administer free water to correct hypernatremia by 6-12 mmol/L/day (faster if hypernatremia happened quickly and patient is symptomatic)
  • DDAVP 1 ug sc or iv
    • OR 10 ug intranasal
    • OR 60-120 ug sublingual melt formulation daily to tid
    • OR 50 (1/2 of 0.1 mg tablet) ug bid po
  • Patient told to drink only when thirsty and to make sure they have breakthrough urination to avoid water intoxication
    • If there is no thirst mechanism, fluctuation in weight can be used to determine correct dose of DDAVP and intake of water

Subscribe to Pearls

Uncle Sam wants you to subscribe to Medical Pearls

Subscribe today! It’s always free, and you can easily unsubscribe at any time. We will never share your email address. Subscribe to...

Multiple Pearls
Cardiology Pearls
Endocrinology Pearls
Hematology Pearls
Nephrology Pearls
Rheumatology Pearls
Transplant Pearls
General Internal Medicine Pearls
Instructor Pearls

Subscribe to receive your pearls today—it's free!