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Endocrinology Question 9 Instructor | Medical Pearls

Endocrinology Question 9 Instructor

List 7 classes of drugs besides insulin that lower glucose, and their main mechanism of action.

Drug Class Mechanism of Action
Biguanide (Metformin) Reduces hepatic glucose production,
Increases insulin sensitivity
Sulfonylureas Insulin release via stimulation of the sulfonylurea receptor
DPP-4 inhibitors
(Sitagliptin/saxagliptin)
Inhibit breakdown of GLP-1, GIP
Incretins that stimulate insulin release in response to diet
GLP-1 analog (Liraglutide) See above
Thiazolidinediones
(pioglitazone, rosiglitazone)
PPARg agonist,
Insulin sensitizer


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