Hematology Question 13 Instructor

What factors cause a factitiously elevated hemoglobin?

Measuring hemoglobin values:

  • Automated cell counter from a tube of well-mixed EDTA-anticoagulated blood filled to a predetermined level.
  • RBCs are lysed, all forms of hemoglobins are converted to the colored protein cyanomethemoglobin and measured by a colorimeter.
  • An inadequate sample, whether due to insufficient volume or inadequate anticoagulation, may give false readings.
  • Hemoglobin is quantified based on its absorption characteristics. Conditions such as hyperlipidemias, hyperbilirubinemia, a very high white blood cell count, and high serum protein can interfere with this measurement and result in falsely elevated hemoglobin values.

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