Hematology Question 15

Paroxysmal Nocturnal Hemoglobinuria has an incidence of 0.13/100,000. What is the primary defect in this disorder and how does it lead to its primary hematologic abnormalities?

  1. What are the main signs/ symptoms of PNH?
  2. What is the leading cause of mortality?
  3. What therapies are efficacious?

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