Hematology Question 24 Instructor

Blood transfusions come with risks and complications. What are the major issues to consider in consenting a patient for a blood transfusion and are the infectious risks of transfused blood product?

  • Common:
    • FNHTR (5% with platelets, <1% with RBCs), allo-immunization to red cell antigens
  • Serious:
    • TACO (1 in 700)
    • TRALI (1 in 5,000)
    • Acute hemolytic transfusion reaction (1 in 40,000)
    • Anaphylactic reaction
    • Bacterial contamination (1 in 40,000)
  • Uncommon:
    • Hepatitis B (1:153,000), Hepatitis C (1:3 million), WNV, HTLV, HIV (1:7.8 million)
    • Emerging pathogens: Chagas
    • Error (1:19,000)

Callum JL et al. Bloody Easy 3. ORBCN; 2011

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