Hematology Question 35

A 22 year old female is referred to your clinic for a lifelong history of easy bruising and heavy menstrual bleeding starting at menarche.

  1. Is this bleeding history significant? Are there any clinical prediction rules that may help in defining pre-hemostatic test probability?
  2. She is found to have von Willebrand disease on hemostatic testing. What is von Willebrand disease?
  3. What is the initial screen for von Willebrand disease? What are the subsequent tests required to further define the diagnosis?

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