Hematology Question 9

A 63 year old male is now 5 days post CABG for left main disease. Pre-op his platelets were 260 x 109/L with an otherwise normal CBC. His platelets are now 70 x 109/L, and the concern is that the patient has HIT.

  1. What is HIT and what is the mechanism of action?
  2. What are the risk factors for HIT?
  3. How is it diagnosed? What is the 4T score?
  4. How should it be managed acutely?

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