Nephrology Question 11 Instructor

What are 7 renal complications of multiple myeloma?

Renal complications in multiple myeloma include:

  • Light chain or cast nephropathy
  • Amyloidosis
  • Light chain deposition disease
  • Fanconi’s syndrome (proximal tubular dysfunction)
  • Hypercalcemia with acute renal failure

Less commonly, one might see:

  • Heavy chain deposition disease
  • Cryoglobulinemia
  • Uric acid nephropathy renal plasma cell invasion

Why might a urine dipstick not be positive for protein even if a patient has large amounts of light chains in their urine?

Urine dipsticks only detect albumin and not all proteins, including light chains. Therefore, a patient with multiple myeloma who has a large amount of light chains in the urine will not have a dipstick positive for albumin.

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