Nephrology Question 21 Instructor

Name 6 diseases that affect the kidney that are associated with hypocomplementemia.

Hypocomplementemia in glomerulonephritis is most often due to increased complement consumption. In these cases, immune deposits cause complement consumption at a greater rate than they can be synthesized. Other less common causes of hypocomplementemia are hereditary complement deficiency and the presence of circulating factors that promote complement activation.

Hypocomplementemia can occur with the following conditions:

  • Lupus nephritis
  • Subacute bacterial endocarditis
  • Membranoproliferative glomerulonephritis (MPGN)
  • Post-streptococcal glomerulonephritis
  • Cryoglobulinemic glomerulonephritis
  • Atheroembolic renal disease
  • Hemolytic uremic syndrome/thrombotic thrombocytopenic purpura.

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