Nephrology Question 23 Instructor

Where do the following diuretics act along the nephron?

  • Acetazolamide
  • Furosemide
  • Hydrochlorothiazide
  • Spironolactone
  • Amiloride

Loop diuretics act in the thick ascending limb of the loop of Henle, thiazide-type diuretics act in the distal tubule and connecting segment (and perhaps the early cortical collecting tubule) and potassium-sparing diuretics act in the aldosterone-sensitive principal cells in the cortical collecting tubule.

  • Acetazolamide is a carbonic anhydrase inhibitor that acts in the proximal convoluted tubule
  • Furosemide blocks the NaK2Cl channel in the thick ascending limb of the loop of Henle
  • Hydrochlorothiazide inhibits the NaCl cotransporter in the distal tubule
  • Spironolactone competitively inhibits the aldosterone mineralocorticoid receptor in the cortical collecting duct
  • Amiloride blocks ENaC (epithelial sodium channel) in the cortical collecting duct

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