Where do the following diuretics act along the nephron?
- Acetazolamide
- Furosemide
- Hydrochlorothiazide
- Spironolactone
- Amiloride
Loop diuretics act in the thick ascending limb of the loop of Henle, thiazide-type diuretics act in the distal tubule and connecting segment (and perhaps the early cortical collecting tubule) and potassium-sparing diuretics act in the aldosterone-sensitive principal cells in the cortical collecting tubule.
- Acetazolamide is a carbonic anhydrase inhibitor that acts in the proximal convoluted tubule
- Furosemide blocks the NaK2Cl channel in the thick ascending limb of the loop of Henle
- Hydrochlorothiazide inhibits the NaCl cotransporter in the distal tubule
- Spironolactone competitively inhibits the aldosterone mineralocorticoid receptor in the cortical collecting duct
- Amiloride blocks ENaC (epithelial sodium channel) in the cortical collecting duct
