List 4 drugs safe to use for hypertension in pregnancy, and 4 reasons why ACE inhibitors are contraindicated.
It is safe to use the following drugs to treat hypertension inpregnancy:
- PO:
- methyldopa
- hydralazine
- labetalol
- nefidipine
- IV:
- hydralazine
- labetalol
- diazoxide
ACE inhibitors are contraindicated in all trimesters of pregnancy. If used, fetal anomalies include oligohydramnios, lung hypoplasia, craniofacial deformity and renal failure.
Reference:
Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA, Dyer S, Gideon PS, Hall K, Ray WA. Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors.
N Engl J Med 354:2443, June 8, 2006 (PubMed)
