Nephrology Question 35 Instructor

List 4 drugs safe to use for hypertension in pregnancy, and 4 reasons why ACE inhibitors are contraindicated.

It is safe to use the following drugs to treat hypertension inpregnancy:

  • PO:
    • methyldopa
    • hydralazine
    • labetalol
    • nefidipine
  • IV:
    • hydralazine
    • labetalol
    • diazoxide

ACE inhibitors are contraindicated in all trimesters of pregnancy. If used, fetal anomalies include oligohydramnios, lung hypoplasia, craniofacial deformity and renal failure.


Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA, Dyer S, Gideon PS, Hall K, Ray WA. Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors.
N Engl J Med 354:2443, June 8, 2006 (PubMed)

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