Rheumatology Question 3 Instructor

What are the clinical features of scleroderma renal crisis? What subset of scleroderma patients is at higher risk of scleroderma renal crisis?

Clinical features of scleroderma renal crisis:

  1. Abrupt onset hypertension
  2. Progressive decline in renal function
  3. Acute retinal changes of hypertensive crisis
  4. Microangiopathic hemolytic anemia
  5. New onset proteinuria
  6. Oliguria or anuria
  7. Flash pulmonary edema
  8. Characteristic kidney biopsy

The highest risk for scleroderma renal crisis is in those with the diffuse subtype of scleroderma. They are most vulnerable within the first 5 years of disease, particularly while skin changes are progressing.

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