Transplant Question 34 Instructor

Compare cyclosporine, tacrolimus, sirolimus, steroids, azathioprine and mycophenolate for their effect on the risk of hypertension, hyperlipidemia, and hyperglycemia post-transplant.

Hypertension is a common side effect of cyclosporine, tacrolimus and steroids.

Hyperlipidemia is more commonly seen with cyclosporine than tacrolimus. Sirolimus and steroids also cause hyperlipidemia.

Hyperglycemia is more common with tacrolimus than cyclosporine. Steroids can also cause hyperglycemia. Sirolimus has also been reported to increase the risk for diabetes.

Azathioprine and mycophenolate do not affect the cardiovascular risk profile.

A summary of the effects on cardiovascular risk factors can be found here.

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