Transplant Question 35

A lung transplant patient is on cyclosporine, azathioprine, and prednisone, along with calcium carbonate, metoprolol, diltiazem, allopurinol, simvastatin, and zopiclone. A urine culture is positive for Candida and Infectious Diseases suggests treatment with fluconazole.

What drug interactions are present with the patient’s current medication regimen that could be of potential clinical significance? How can you monitor for evidence of toxicity related to these drug interactions? What other drugs interact with immunosuppressants?

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