Hematology Question 1 Instructor

Question: traditionally the pathogenesis of thrombosis is based upon Virchow’s Triad: stasis, hypercoagulability and endothelial injury. What are the most common risk factors for venous thromboembolism?

Risk factors for VTE are predicated on Virchow’s Triad and include but are not limited to:

    1. Factor V Leiden Mutation
    2. Prothrombin Gene Mutation
    3. Protein S deficiency
    4. Protein C deficiency
    5. Anti-thrombin Deficiency
  2. Malignancy and myeloproliferative neoplasms
  3. Prolonged Immobilization (surgery, trauma)
  4. Venous catheters
  5. Medications (OCPs, HRT, anti-neoplastic agents)
  6. Anti-phospholipid antibodies
  7. Pregnancy
  8. Nephrotic Syndrome
  9. Inflammatory Bowel disease
  10. Rare: Paroxysmal Nocturnal Hemoglobinuria

Lijfering WM, Rosendaal FR, Cannegieter SC. Risk factors for venous thrombosis – current understanding from an epidemiological point of view. Br J Haematol 2010; 149:824.

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