Rheumatology Question 27

Cyclophosphamide is an alkylating agent that crosslinks DNA so that it cannot replicate, resulting in double stranded DNA breaks. It is cytotoxic to resting and dividing lymphocytes, and acts to suppress primary cellular and humoral immune responses. It is considered to be one of the most potent immunosuppressive drugs available.

List four side effects associated with cyclophosphamide use. Are there ways to minimize cyclophosphamide toxicity?

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